Tuesday, October 18, 2016

Some Research I Published Recently on Perinatal Outcomes from Gamete Donation

A meta-analysis of neonatal health outcomes from oocyte donation.
J Dev Orig Health Dis. 2015 Nov 27:1-16.
Adams DH, Clark RA, Davies MJ, de Lacey S.
Abstract
Donated oocytes are a treatment modality for female infertility which is also associated with increased risks of preeclampsia. Subsequently it is important to evaluate if there is concomitant increased risks for adverse neonatal events in donated oocyte neonates. A structured search of the literature using PubMed, EMBASE and Cochrane Reviews was performed to investigate the perinatal health outcomes of offspring conceived from donor oocytes compared with autologous oocytes. Meta-analysis was performed on comparable outcomes data. Twenty-eight studies were eligible and included in the review, and of these, 23 were included in a meta-analysis. Donor oocyte neonates are at increased risk of being born with low birth weight, very low birth weight, preterm, of lower gestational age, and preterm with low birth weight, when compared with autologous oocyte neonates. Conversely, low birth weight outcomes were improved in term donor oocyte neonates. These negative outcomes remained significant when controlling for multiple deliveries. The donor oocyte risk rates are higher than those found in general ART outcomes, are important considerations for the counselling of infertile patients and may also influence the long term health of the offspring.

https://www.cambridge.org/core/journals/journal-of-developmental-origins-of-health-and-disease/article/a-meta-analysis-of-neonatal-health-outcomes-from-oocyte-donation/42F0997B000AFA5D4C1FB564C32F4A78


A meta-analysis of sperm donation offspring health outcomes.
J Dev Orig Health Dis. 2016 Aug 30:1-12.
Adams DH, Clark RA, Davies MJ, de Lacey S.
Abstract

Although the use of donor sperm as a treatment modality for male infertility has become common place, the health outcomes for those conceived has been poorly studied. A structured search of the literature using PubMed, EMBASE and Cochrane Reviews was performed to investigate the health outcomes of offspring conceived from donor sperm. Eight studies were eligible and included in the review, and of these, three were included in a meta-analysis. Meta-analysis of clinical outcomes showed that donor sperm neonates are not at increased risk of being born of low birth weight, preterm or with increased incidences of birth defects, than spontaneously conceived neonates.

https://www.cambridge.org/core/journals/journal-of-developmental-origins-of-health-and-disease/article/a-meta-analysis-of-sperm-donation-offspring-health-outcomes/9D80FB804E60348888F5703B01F0F0CD