Thursday, August 17, 2017

Sperm donation perinatal outcomes in an Australian population cohort

This is a newly published study that I coauthored with some colleagues on perinatal outcomes after sperm donation.

Sperm donation perinatal outcomes in an Australian population cohort


Authors: Damian Adams, Renae Fernandez, Vivienne Moore, Kristyn Willson, Alice Rumbold, Sheryl de Lacey, Wendy Scheil, Michael Davies

Abstract
Aim
To compare perinatal outcomes for neonates conceived with donated sperm with those for neonates conceived spontaneously in an Australian population cohort.
Methods
Perinatal outcomes for all births in South Australia for the period January 1986–December 2002 were linked with assisted reproductive treatment records to determine those conceived from donated sperm. Birth outcome measures were analyzed using Student's t-test and logistic regression using generalized estimating equations to determine statistical significance.
Results
Donor sperm neonates were not significantly different from their spontaneously conceived counterparts in terms of mean birthweight, low birthweight, preterm delivery, small for gestational age, or large for gestational age. They were, however, significantly more likely to be born at lower mean gestational age (P = 0.012), and to have preterm delivery with low birthweight (P = 0.008), when controlling for maternal age, parity, ethnicity, socioeconomic quartile and baby's sex. These associations were not apparent when singletons and twins were considered separately.
Conclusion
There was some evidence of compromised perinatal outcomes for donor sperm neonates compared with their spontaneously conceived counterparts, which appeared to be partly attributable to multiplicity.

No comments: