Tuesday, October 18, 2016

Some Research I Published Recently on Perinatal Outcomes from Gamete Donation

A meta-analysis of neonatal health outcomes from oocyte donation.
J Dev Orig Health Dis. 2015 Nov 27:1-16.
Adams DH, Clark RA, Davies MJ, de Lacey S.
Abstract
Donated oocytes are a treatment modality for female infertility which is also associated with increased risks of preeclampsia. Subsequently it is important to evaluate if there is concomitant increased risks for adverse neonatal events in donated oocyte neonates. A structured search of the literature using PubMed, EMBASE and Cochrane Reviews was performed to investigate the perinatal health outcomes of offspring conceived from donor oocytes compared with autologous oocytes. Meta-analysis was performed on comparable outcomes data. Twenty-eight studies were eligible and included in the review, and of these, 23 were included in a meta-analysis. Donor oocyte neonates are at increased risk of being born with low birth weight, very low birth weight, preterm, of lower gestational age, and preterm with low birth weight, when compared with autologous oocyte neonates. Conversely, low birth weight outcomes were improved in term donor oocyte neonates. These negative outcomes remained significant when controlling for multiple deliveries. The donor oocyte risk rates are higher than those found in general ART outcomes, are important considerations for the counselling of infertile patients and may also influence the long term health of the offspring.

https://www.cambridge.org/core/journals/journal-of-developmental-origins-of-health-and-disease/article/a-meta-analysis-of-neonatal-health-outcomes-from-oocyte-donation/42F0997B000AFA5D4C1FB564C32F4A78


A meta-analysis of sperm donation offspring health outcomes.
J Dev Orig Health Dis. 2016 Aug 30:1-12.
Adams DH, Clark RA, Davies MJ, de Lacey S.
Abstract

Although the use of donor sperm as a treatment modality for male infertility has become common place, the health outcomes for those conceived has been poorly studied. A structured search of the literature using PubMed, EMBASE and Cochrane Reviews was performed to investigate the health outcomes of offspring conceived from donor sperm. Eight studies were eligible and included in the review, and of these, three were included in a meta-analysis. Meta-analysis of clinical outcomes showed that donor sperm neonates are not at increased risk of being born of low birth weight, preterm or with increased incidences of birth defects, than spontaneously conceived neonates.

https://www.cambridge.org/core/journals/journal-of-developmental-origins-of-health-and-disease/article/a-meta-analysis-of-sperm-donation-offspring-health-outcomes/9D80FB804E60348888F5703B01F0F0CD

Tuesday, February 23, 2016

Victoria creates new legislation that gives ALL donor conceived people the right to their heritage

From:
http://www.premier.vic.gov.au/new-law-gives-all-donor-conceived-victorians-the-right-to-know-their-heritage/

All donor-conceived Victorians will now be able to access available identifying information about their donors and heritage from 1 March 2017 without donor consent.
The Assisted Reproductive Treatment Act Amendment Bill 2015 tonight successfully passed through the Victorian Legislative Council without amendment.
Previously, only people born from sperm or eggs donated after 1998 could automatically find out available identifying information about their donors when they reach adulthood.
Changes to the law in 2015 meant donor-conceived people born before 1998 could access this information, but only with donor consent.
The new law addresses this inequality and recognises that it is important for all donor-conceived Victorians to access information about their heritage, no matter when their donors donated.
From 1 March 2017, the Andrews Labor Government’s amendments will mean that people born before 1998 will be able to access the same identifying information without the need for the donor’s consent.
Knowledge about one’s heritage can contribute to a person’s sense of identity and is critical for medical treatments and family planning.
The Victorian Assisted Reproductive Treatment Authority will manage access to information about donors and provide counselling and support for donors, donor-conceived people and their families.
The new laws establish contact preferences for donors who donated pre-1998 to manage contact or choose no contact, with their donor-conceived offspring. This recognises that these donors donated on the expectation that they could remain anonymous.
Donor-conceived people will also be able to lodge contact preferences where their donors seek identifying information about them.
Quotes attributable to Minister for Health Jill Hennessy
“We believe all donor-conceived people should have the right to know about their genetic heritage, no matter when their donors donated.”
“This information can make a huge difference to the lives of donor-conceived Victorians. If this information is available, it shouldn’t be kept from them.”
“I wish to acknowledge the work of the Parliament in passing this important piece of legislation.”